Chronic Obstructive Pulmonary Disease

At Cellular Hope institute we treat chronic lung disease, including chronic obstructive pulmonary disease (COPD), emphysema and chronic bronchitis. Many of these conditions have no cure, but certain Regenerative medicine treatments can help patients breathe better.

Our treatment harnesses your own natural biological components that can help reduce inflammation in the lungs, regenerate lung structure and induce lung functional recovery through reduction of inflammation, and induction of immunomodulation.

COPD is caused by a combination of small airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema). The pathophysiology of COPD is mediated primarily by a pathogenic triad: inflammation, oxidative stress, and protease-antiprotease imbalance. The inflammatory process in the lungs of COPD patients involves concentration of macrophages, neutrophils, CD8+ cytotoxic lymphocytes in the small airways and the subsequent release of humoral factors cytokines, chemokines, and elastolytic enzymes.

At Cellular Hope institute we treat chronic lung disease, including chronic obstructive pulmonary disease (COPD), emphysema and chronic bronchitis. Many of these conditions have no cure, but certain Regenerative medicine treatments can help patients breathe better. Our treatment harnesses your own natural biological components that can help reduce inflammation in the lungs, regenerate lung structure and induce lung functional recovery through reduction of inflammation, and induction of immunomodulation.

COPD is caused by a combination of small airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema). The pathophysiology of COPD is mediated primarily by a pathogenic triad: inflammation, oxidative stress, and protease-antiprotease imbalance. The inflammatory process in the lungs of COPD patients involves concentration of macrophages, neutrophils, CD8+ cytotoxic lymphocytes in the small airways and the subsequent release of humoral factors cytokines, chemokines, and elastolytic enzymes.

Experience our Individually-Center approach for deep regeneration and wellbeing through our leading-edge cellular therapies

Adipose Stem Cell Delivery in COPD
Can Stem Cells Cure My Medical Condition?
What are the different cellular therapies available for me?
Which Are The Different Administration Methods That We Use At Our Centers?
Why undertake a treatment with highly-manipulated cells outside of the United States?
What To Expect When getting to our Center Treatment Center?
What’s Included as Part of our Treatment?
Understanding Your Stem Cell Treatment
When Will I See Results?
How Do We Follow-Up Our Treatments Once Patients Return Home?
Are There Risks Involved With Stem Cell Extraction?
Understanding your condition
Adipose Stem Cell Delivery in COPD

In the case of autologous adipose tissue transfers, many procedures harvest cells from the bone marrow via puncture of the iliac crest, which can increase the risk for infection and considerable pain. In addition, subcutaneous adipose tissue yields 500 times the amount of cells that bone marrow does. Thus far, most of the procedures in human trials have involved autologous transfers of adipose stem/stromal cells (ASC).

Adipose derived – Mesenchymal Stem cells can differentiate into several different lung cell types such as the alveolar epithelial cells that are destroyed by cigarette smoke leading to emphysematous changes and reduced tethering of small airways causing hyperinflation and gas exchange abnormalities. Pre-clinical trials in animal models have suggested regeneration of alveolar-like structures, repair of emphysematous lungs, and reduction of inflammatory responses.

Regenerative medicine is now increasingly being used to treat various conditions and COPD is not exempt.

CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Chronic obstructive pulmonary disease, or COPD, is an umbrella term for chronic conditions that limit airflow in the lungs. This can cause symptoms like breathlessness and severe coughing, as well as wheezing and chest tightness. It’s most often caused by pollutants like tobacco smoke and chemicals or fumes. It can also be genetic, meaning you can still develop it even if you don’t have other risk factors. COPD is progressive and requires early treatment to ensure that you can live a healthy lifestyle and avoid limitations.

Can Stem Cells Cure My Medical Condition?

When we treat a medical condition, we are just treating the condition, not curing it. Neither fresh cells nor cultured cells can cure every disease, but they can do great things as far as reducing the severity of symptoms and stopping the advancement of the condition. Normally, in a lot of chronic degenerative conditions or neurological conditions, several treatments will be needed because the effect of cellular therapies has a time limit. Our unique approach includes a multi-dose treatment plan, in which we apply the cells once, with follow-ups at three, six, and nine month mark. If symptoms begin to occur, another round of treatment is needed.

What are the different cellular therapies available for me?

Our comprehensive stem cell treatment protocols employ well-targeted combinations of Exosomes, allogeneic human Mesenchymal cells, and autologous bone marrow and Adipose derived stem cells to treat the  diseases and conditions listed previously. Our treatment plans are mostly focused on a systemic or whole-body approach to ensure these patients receive the highest quality and quantity of cellular products during their time in our hospital

Of the different kinds of cellular products available for use, there are two main sources that can be used to target the conditions that have been previously discussed.

Autologous procedures are those in which the patient is their own donor for the cellular therapy treatment. In these kinds of procedures, a doctor takes a sample (usually of bone marrow or adipose tissue) and harvests the cells from it, before administering it locally to the diseased or damaged area. 

Allogeneic procedures are those in which the patient receives cells that have been sourced from a donor that is not the patient. These samples are neonatal tissue and are comprised of umbilical cord blood. They are extensively screened to ensure the quality and health of the cells. 

The type of treatment used depends on a variety of factors, including medical history and age, but at the Cellular Hope Institute, we endeavor to give each patient a personalized, case-by-case treatment plan to ensure that the only possible outcome is a positive one.

Which Are The Different Administration Methods That We Use At Our Centers?

After you’ve been selected as a candidate, you will meet with our highly-trained team of medical professionals to devise a treatment plan tailored specifically to have the best results possible given your current condition. Below we will outline the different methods of administering cellular therapies that we use in our medical facilities:

intrathecal-intraarterial
This form of implantation is ideal for neurological conditions because the stem cells are injected past the blood-brain barrier and directly into the spinal fluid, which enables them to reach the spinal cord and brain.

During the procedure, an experienced anesthesiologist inject stem cells into the spinal canal through the lower vertebrae under local anesthesia. They are all performed in a positive airflow room under sterile conditions, and the procedure usually takes about thirty minutes.

Intravenous IV
The safest and simplest method for delivering the stem cells throughout the body. Anesthesia is not required. We may use Lidocaine topical spray to needle prick area beforehand. IV administration usually takes about 20 – 30 minutes.

Intramuscular IM
The stem cells are injected directly into the muscle. Intramuscular implantation is very safe and does not require anesthesia.

Why undertake a treatment with highly-manipulated cells outside of the United States?

A treatment of minimally manipulated, or autologous, stem cells is one in which the patient’s own cells are used to treat their illness without being grown in a laboratory setting. These treatments, while minimally invasive, can only reach a third of the total cell count that could be obtained under more complex laboratory processes, leaving them useful for certain conditions, but not potent enough for more advanced degenerative or neurodegenerative conditions. 

 

Highly-manipulated cellular therapies are those that use a laboratory to culture and expand cells through the cell’s population. Through this process, samples of cells are grown to contain larger quantities of Mesenchymal Stem Cells, which leads to better patient results. In the case of complex conditions, including chronic degenerative conditions or neurodegenerative conditions, the best results are obtained through an infusion of a larger amount of cells directly to the diseased area. This is an invasive procedure, and because of that it requires a large, highly-specialized medical team to carry it out. That is the reason why many patients are opting to find the best results in the best facilities available, which are overseas, since current regulations prevent practices in the States from treating their patients in this manner.

What To Expect When getting to our Center Treatment Center?

The Cellular Hope Institute’s offices are located in the Amerimed Hospital in Cancun, which is accredited both by the Mexican General Health Council and the Canadian Accreditation Council. There, we have a highly-qualified team in many specialties, including pediatricians, radiologists, neurologists, anesthesiologists and regenerative medicine specialists, who convene with each other to produce the most reliable, efficable patient experience available.

Aside from it’s proximity to the United States and pleasant climate and sights, Our facilities in Cancun are top-notch, and include a laboratory to culture-expand cells, a process that yields better patient results, and a cryopreservation unit to keep these extracted samples stored safely until they are needed.

What’s Included as Part of our Treatment?

Before the first day of treatment, we go over the patient’s medical history, including previous and current treatments including physical therapy and cognitive therapy. We interview the patients to know more about them in order to form a custom treatment plan. On your first day in Cancun, we have scheduled a time for you to meet your medical team and ask them any questions you have, as well as for them to walk you through the treatment you will be undergoing. 

Services Included In Your Treatment

  • Medical general assessment. 
  • Critical care evaluation. 
  • Specialist doctor evaluation. 
  • Anesthesiology evaluation. 
  • Perioperative care. 
  • Pharmacy and Supplies. 
  • Operating room.
  • Anesthesia Services. 
  • Diagnostic/therapeutic imaging. 
  • Autologous stem cell acquisition. 
  • Pathology services. 
  • Hemodynamics suite.
  • Patient coordination fee.
  • Catheterization procedure.
  •  Mannitol injection.
  • Med Surg Supplies sterile.
  • Spinal tap procedure.
  • Recovery.
  • Laboratory fee.
  • Culture/Expansion autologous BM derived stem cells.
  • Med Surg room.
  • IV infusion.
  • Follow up and recommendations.
  • Pick up / Drop off from airport to accommodation and vice versa.
  • Pick up/ Drop Off the day of the procedure to and from hospital.
Understanding Your Stem Cell Treatment

Your journey will begin as you depart from your hometown for beautiful Cancún, México. In Cancún they will be greeted at the International Airport by our patient coordinator, then transferred to your accommodations. Once settled in, the patient coordinator will provide them a welcome package that will contain:

          • City vouchers.
          •  A list of frequently asked questions.
          • Contact info during your stay.

First Consultation
The day before your procedure takes place, you will have a one-on-one with your specialized team, at which point your attending physician will go over your procedure and expectations. At this time, you may ask your doctor any additional questions you may have. This day will include:

          • Analysis of current condition of the patient.
          • New lab tests run.
          •  Specialist doctor evaluation according to the medical condition to be treated.
          • Anesthesia evaluation.
          • Establishment of final protocols to follow according to previous indicators.

Treatment Day
You will be picked up two hours before the procedure is scheduled to begin, please ensure that you do not eat eight hours before the procedure.  

Once you arrive at the hospital you will be asked to sign all the necessary patient consent forms and you will be prepped for your procedure.

The procedure will take 3-4 hours, once the cells are harvested and prepared they will be administered to the patient in accordance with their . After the procedure is complete you will either be returned to your hotel or, depending on the procedure, your hospital suite for overnight observation.

A standard procedure for highly manipulated stem cells cell would be the following:
Extraction of bone marrow or fat sample. In the case of young children, who do not have very much adipose tissue, a bone marrow extraction through the iliac crest (hip bone) is usually performed. 

Procedure is performed with local anesthesia and sedation, meaning there is little pain.After the sample is extracted, it is processed and isolated to obtain fresh mesenchymal cells. Approximately 80% of the mesenchymal cells obtained go directly to the patient, either through arterial catheterization in the case of neurological illness, or intrathecally to other damaged organs. The other 20% are sent to the lab to be expanded, a process which is known as the high manipulation of stem cells. The patient stays overnight for close clinical motoring.

Post-Operative Care
The day after the patient’s procedure, you will go to your follow up appointment, where your garment and bandages will be removed, your incisions will be cleaned and inspected, and you will get your first ultrasound scan. 

Booster with highly manipulated stem cells:
(Sixth day stay). The physician or patient coordinator will notify you for the procedure with the stem cells that have been expanded in the laboratory. The patient receives a final booster through systematic approach via intravenous line with the cultured cells. 

After this, the physician team will make a final evaluation and, most likely, discharge the patient. 

Departure day
A driver will pick you and the patient up at your accommodation, and you will be dropped off at the airport at least two hours prior to your flight’s departure. Your patient coordinator will let you know when the next virtual consultation will take place.

When Will I See Results?

After the first dose, results can already begin to make themselves apparent, but this depends largely on the type of disease/condition the patient is afflicted with, as well as its severity and current phase of progression. Once the stem cell treatment begins, the body needs a minimum of four weeks to recognize the initial regenerative effects, which become more apparent at the six-month mark. Regenerative medicine is considered a multi-dose treatment, and reinforcements are usually required every six to twelve months. However, depending on a patient’s condition, they could be needed up to twenty-four months after the initial procedure. This is why cryogenically banking and storing stem cells is extremely important.

How Do We Follow-Up Our Treatments Once Patients Return Home?

There is a virtual Assessment for Follow-Up treatment that serves as monitoring for the patient’s condition, and will be requested both before and after the treatment. In addition, there will continue to be post-treatment assessments required.

Are There Risks Involved With Stem Cell Extraction?

While stem cell therapy is an extremely safe alternative to many other invasive surgeries and therapies, it is not without its risks. However, these risks can be mitigated by selecting highly-trained, certified experts to perform your procedure. At The Cellular Hope Institute, we take every possible step and procedure to ensure a safe surgery conducted as quickly as can be safely done. During your consultation, you can bring forward any other questions or expectations with our expert physicians.

Understanding your condition

The main cause of COPD in developed countries is tobacco smoking. In the developing world, COPD often occurs in people exposed to fumes from burning fuel for cooking and heating in poorly ventilated homes.

Only about 20 to 30 percent of chronic smokers may develop clinically apparent COPD, although many smokers with long smoking histories may develop reduced lung function. Some smokers develop less common lung conditions. They may be misdiagnosed as having COPD until a more thorough evaluation is performed.

The difficulties of pharmacological treatment in some phenotypes of the disease are not able to give an adequate therapeutic response to patients. The bronchodilator drugs and topical steroids are symptomatic and only slow the evolution of lung disease.

Our primary focus of treatment is to reduce the inflammation of the lungs. Usually when the stem cells are administered through an IV, they pass through a pulmonary track which essentially captures the stem cells where they are most needed in the patient’s body.

Those stem cells and growth factors may then be effective at reducing inflammation within the lungs.

The difficulties of pharmacological treatment in some phenotypes of the disease are not able to give an adequate therapeutic response to patients. The bronchodilator drugs and topical steroids are symptomatic and only slow the evolution of lung disease.

Our primary focus of treatment is to reduce the inflammation of the lungs. Usually when the stem cells are administered through an IV, they pass through a pulmonary track which essentially captures the stem cells where they are most needed in the patient’s body.

Those stem cells and growth factors may then be effective at reducing inflammation within the lungs.

CONTACT US

Cellular Hope Institute – Datran Center 9100 S Dadeland Boulevard, Suite 1500. Miami Fl. 33156 United States

305 560 5337

info@cellularhopeinstitute.com

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